Neural Stem Cell Therapy for Ischemic Stroke Patients

March 15, 2011 | by

The single largest cause of adult disability in the developed world is ischemic stroke, in which blood flow in or to the brain is blocked. It precipitates immense amounts of social and financial costs. Currently, therapies for stroke focus on prevention or acute phase treatments that arrest the stroke while it is happening. But many patients are not fortunate enough to get acute phase treatment and suffer neurological damage that leads to functional and cognitive impairment. Until now, there have been almost no options for such patients. But last February, a company called ReNeuron received approval to begin a clinical trial of neural stem cell therapy for disabled stroke patients [1]. Two patients have been treated thus far and the therapy appears to be safe.

Neural stem cell therapy

Vitamin D Regulates Genes Associated with Susceptibility to Autoimmune Diseases

March 10, 2011 | by

Vitamin D is, at this point, probably one of the trendiest vitamins around. Everyone suddenly seems to be getting their vitamin D level tested (specifically vitamin D3 or 25(OH)D, also called calcidiol) and, when levels are found to be deficient, taking supplements. In November 2010, the Institute of Medicine tripled its daily recommendations for vitamin D from 200 International Units to 600 [1]. Severe vitamin D deficiency causes rickets, which leads to a softening and weakening of the bones, so milk has been fortified with vitamin D to prevent rickets. Less dramatic vitamin D deficiency has been implicated in ailments ranging from cancer to heart disease to schizophrenia to autoimmune diseases to colds and the flu. But how does vitamin D act in the body — how can it contribute to so many different physiological processes?

Functions of vitamin D

Crizotinib: Another Step Towards Personalized Cancer Care

February 9, 2011 | by

Tyrosine kinases are signaling molecules that are frequently mutated as cells become tumorigenic. One of their responsibilities is regulating a cell’s growth based on the extracellular signals they receive. The presence of extracellular growth factors tells them to induce the cell to grow more rapidly, while a lack of oxygen or nutrients tells them to grow more slowly. When these kinases are mutated they make the cell grow uncontrollably, divorcing growth from the conditions outside the cell. In some cases, this mutation is what makes a cell cancerous.

Daily Aspirin May Reduce Cancer Risk

February 2, 2011 | by

It is old news that aspirin is good for your heart. But a recent report published in The Lancet, the premiere medical journal in the United Kingdom, claims that at least 75mg of aspirin every day can also reduce the risk of developing many different types of cancers.

There is already evidence that taking aspirin every day for five years can reduce the risk of colorectal cancer. Moreover, aspirin has been shown to reduce the incidence and/or growth rate of a number of cancers in animal models. To determine if aspirin can reduce the risk of other cancers in humans, Peter Rothwell and colleagues at the University of Oxford undertook a meta-analysis of eight randomized trials originally performed to study aspirin’s role in preventing vascular events. This study was independent of any commercial interests.

Easter Seals Living With Disabilities Study

January 5, 2011 | by

Most of us take everyday adult life for granted; we have a place to live, access to transportation and the opportunity to live independently. The same can most likely be said for those of us with adult children. The basics are covered. But what happens if you’re one of the millions of adults living with a developmental disability in this country? What if you’re the parent and caregiver to an adult child with a disability? How is your life different? Are the basics covered?

When people with disabilities turn 21, they and their families are no longer eligible for the services and supports provided by law through the school system. To determine how this affects them, Easter Seals — the nonprofit, community-based health agency dedicated to helping children and adults with disabilities attain greater independence — commissioned Harris Interactive to perform an online poll of adults with disabilities and their parents [1]. The primary goals of the study were to call attention to the challenges these people face, help service providers better respond to their needs, and heighten awareness of the needs of adults living with disabilities and their families.