Health Highlights – September 30th, 2007

September 30, 2007 | by

Health Highlights is a biweekly summary of particularly interesting articles from credible sources of health and medical information that we follow & read. For a complete list of recommeded sources, see our links page.

Health Highlights

Consortium to Identify Genetic Markers that Predict Drug-related Serious Adverse Events

September 27, 2007 | by

The International Serious Adverse Events Consortium (SAEC) officially announced its formation this morning. The new global, non-profit partnership between leading pharmaceutical companies, pharmacogeneticsthe U.S. Food and Drug Administration (FDA), and academic institutions plans to identify and validate genetic markers that may help predict which individuals are at risk for serious adverse drug events. The goal of the consortium is to publish a set of predictive SNPs for all drug-related serious adverse events (SAEs), reducing significant patient and economic costs as well as improving the flow of safe and effective medical advances by addressing safety issues of new drugs before they reach the market.

Consortium to Identify Genetic Markers that Predict Drug-related Serious Adverse Events

September 27, 2007 | by

The International Serious Adverse Events Consortium (SAEC) officially announced its formation this morning. The new global, non-profit partnership between leading pharmaceutical companies, pharmacogeneticsthe U.S. Food and Drug Administration (FDA), and academic institutions plans to identify and validate genetic markers that may help predict which individuals are at risk for serious adverse drug events. The goal of the consortium is to publish a set of predictive SNPs for all drug-related serious adverse events (SAEs), reducing significant patient and economic costs as well as improving the flow of safe and effective medical advances by addressing safety issues of new drugs before they reach the market.

Treating Cancer with Personalized Medicine

September 24, 2007 | by

A Michigan oncologist recently devised a simple experiment to help treat seven patients with advanced, incurable cancer. The experiment used DNA microarray technology to analyze each patient’s tumors for the expression of genes associated with positive response to anti-cancer drugs. The oncologist, Dr. Eric Lester, M.D., then based his drug treatment plans on the results. Four of seven patients are reported to have had a better outcome than expected [1].

microarrayAlthough every cell in the body contains identical genetic material, the same genes are not active in every cell. Tumor cells are no exception. Cancer refers to any one of a large number of diseases characterized by abnormal cell growth and proliferation. Few of these diseases can be treated in the same way, since the genes responsible for a variety of biological processes — DNA duplication, cellular proliferation, cell death — are different from one tumor to the next.

Treating Cancer with Personalized Medicine

September 24, 2007 | by

A Michigan oncologist recently devised a simple experiment to help treat seven patients with advanced, incurable cancer. The experiment used DNA microarray technology to analyze each patient’s tumors for the expression of genes associated with positive response to anti-cancer drugs. The oncologist, Dr. Eric Lester, M.D., then based his drug treatment plans on the results. Four of seven patients are reported to have had a better outcome than expected [1].

microarrayAlthough every cell in the body contains identical genetic material, the same genes are not active in every cell. Tumor cells are no exception. Cancer refers to any one of a large number of diseases characterized by abnormal cell growth and proliferation. Few of these diseases can be treated in the same way, since the genes responsible for a variety of biological processes — DNA duplication, cellular proliferation, cell death — are different from one tumor to the next.