To remain competitive in our 21st century global economy, the nation must foster new opportunities, approaches, and technologies in math and science education. This begins with a coordinated effort to bolster science, technology, engineering, and math (S.T.E.M.) education nationwide, starting at the earliest stages in education. Developing a more diverse and academically prepared workforce of individuals in S.T.E.M. disciplines will benefit all aspects of scientific and medical research and care.