Oxidative Stress in Children with Celiac Disease

October 21, 2010 | by
ResearchBlogging.org

Celiac disease is a genetic digestive disorder triggered by consumption of the protein gluten, which is found in bread, pasta, cookies, pizza crust and many other foods containing wheat, barley or rye. Researchers now report that there is a factor independent of diet that contributes to oxidative stress in celiac disease patients; children with celiac disease have higher than normal levels of two oxidative DNA damage biomarkers, regardless of what they eat [1].

Celiac disease is an autoimmune disease in which the consumption of gluten — a protein found in all forms of wheat, including spelt, kamut, semolina and triticale, as well as in barley and rye — induces an inflammatory reaction that destroys the gut. It occurs in almost 1% of the population, although in the United States as many as 97% of cases remain undiagnosed. Most autoimmune diseases are thought to be caused by an interaction between a genetic predisposition and an environmental trigger, but celiac disease is the only one for which the environmental trigger is known: gluten.

Vitamin D Status is Not Associated with Risk for Less Common Cancers

June 18, 2010 | by

Despite hopes that higher blood levels of vitamin D might reduce cancer risk, a large study finds no protective effect against non-Hodgkin lymphoma or cancer of the endometrium, esophagus, stomach, kidney, ovary, or pancreas. In this study, carried out by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, and many other research institutions, data based on blood samples originally drawn for 10 individual studies were combined to investigate whether people with high levels of vitamin D were less likely to develop these rarer cancers. Details of these analyses appear as a set of papers in the June 18, 2010, online issue of the American Journal of Epidemiology, and in print in the July 2010 issue.

“We did not see lower cancer risk in persons with high vitamin D blood concentrations compared to normal concentrations for any of these cancers,” said Demetrius Albanes, M.D., NCI, one of the study investigators. “And, at the other end of the vitamin D spectrum, we did not see higher cancer risk for participants with low levels.”

Cancer Research Blog Carnival #21 – National Cancer Research Month

May 1, 2009 | by

Welcome to the 21st edition of the Cancer Research Blog Carnival, the monthly blog carnival that discusses what’s new in cancer research and includes posts covering cancer biology, cancer genetics, cancer diagnostics and cancer therapeutics. Concomitant with this edition is the start of National Cancer Research Month.

There’s a revolution occurring on the Web: those “authoritative” articles written on traditional, static websites are being replaced with blogs, wikis and online social networks. In the sphere of health, medicine and information technology, this “real-time Web” consists of many who are professionals in the field; their posts are listed below.
In the digital age, these are the characteristics of new media: recent, relevant, reachable and reliable.

In 2007, the United States Congress declared May National Cancer Research Month. The American Association for Cancer Research (AACR) secured resolutions to raise awareness of the critical advances in cancer research made by its 27,000 members and cancer researchers worldwide, and its efforts to ensure a secure future for continued progress against a group of diseases which strike one in every two men and one in every three women.

national-cancer-research-month

Today, ten million cancer survivors are alive in America due to advances in cancer research [1]. National Cancer Research Month reminds us that basic, clinical, epidemiological and behavioral research are essential to identifying causes and developing strategies for cancer prevention, diagnosis, treatment and cures.

With that, let’s find out more about what’s happening in cancer research this month.

Cancer Research Blog Carnival #13 – Stand Up To Cancer

September 5, 2008 | by

Welcome to the 13th edition of the Cancer Research Blog Carnival, the blog carnival devoted to cancer research.

There’s a revolution occurring on the Web: those “authoritative” articles written on traditional, static websites are being replaced with blogs, wikis and online social networks. In the sphere of health, medicine and information technology, this “real-time Web” consists of many who are professionals in the field; their posts are listed below.
In the digital age, these are the characteristics of new media: recent, relevant, reachable and reliable.

Everyone knows that cancer is a devastating disease. What many people don’t know is that cancer kills more than 1,500 people a day; that’s one person every minute. Tonight, Stand Up To Cancer, a one-hour fundraising event, will be simulcast on all three major U.S. networks. The goal of Stand Up To Cancer (SU2C) is to enable cutting-edge research aimed at finding a cure to all types of cancer and making cancer part of the national debate.

Since 2001, federal deficits resulting from a number of fiscal pressures, including the wars in Afghanistan and Iraq, increased national defense spending and hurricane Katrina, have together placed significant stress on the resources available for U.S. biomedical research. Between the fiscal years 2004 and 2007, the National Cancer Institute’s budget remained relatively flat. However, factoring in inflation (i.e. a Biomedical Research and Development Price Index (BRDPI) of ~3.8% per year) reveals a 12% loss of purchasing power [1].

This decrease in resources comes as patient demand is growing. There was an estimated 1.5 million new cancer cases in 2007, an increase of 14% since 2001 [2]. The U.S. spends roughly $12 billion dollars every month fighting the wars in Afghanistan and Iraq. That’s 33 times more than what is spent on cancer research annually. Imagine what we could do if just a fraction of those resources was dedicated to cancer research.