The impact of the Patient Protection and Affordable Care Act (PPACA) will be front and center later this week when the Food and Drug Administration (FDA) decides whether to revoke marketing clearance of the cancer drug Avastin for breast malignancies.

On one side, you have critics of the FDA accusing them of rationing healthcare while on the other side, you have comparative effectiveness research showing that there’s no statistically meaningful difference in the survival of patients receiving Avastin plus chemotherapy compared to chemotherapy alone.