Between 1996 and 2007, use of herbal supplements in the U.S. rose by a staggering 83% [1]. Many people use herbal medicines mistakenly believing them to be safe simply because they are ‘natural’. However, just like conventional drugs, herbal medicines alter normal body physiology. And despite their wholesome image, many herbal products have adverse effects and may have dangerous interactions with other drugs and dietary supplements. New research published in BioMed Central’s open access journal BMC Medicine reveals that most over-the-counter herbal products do not contain any of the key information required for safe use [2].