Body Clock Strength Impacts Bipolar Disorder

March 16, 2012 | by

Bipolar Disorder, also known as manic–depressive disorder, is a condition characterized by alternating states of elevated energy, cognition and mood, with periods of irritable mood and depression. The extreme mood swings experienced by patients with bipolar disorder have been strongly associated with disruptions in circadian rhythms — the 24-hour cycle of biological processes that govern our day and night activity.

Lithium is one of the most common treatments for bipolar disorder. However, little research has been done to find out if and how lithium impacts the brain and peripheral body clockwork. A new study published in the open access journal PLoS ONE reveals a novel link between lithium, bipolar disorder and circadian rhythms [1].

Bipolar Disorder

A Light Switch to Turn Specific Neurons On and Off

March 14, 2012 | by

Ed Boyden is creating new brains. A pioneer in the field of optogenetics, he is the founder and principal investigator of the synthetic neurobiology group at the MIT Media Lab, which invents technologies to reveal how cognition and emotion arise from brain networks — and to enable systematic repair of disorders such as epilepsy and post-traumatic stress disorder (ptsd).

Using a combination of lasers and genetic engineering, Boyden’s lab implants brains with optical fibers that allow them to activate special proteins in specific neurons and see their connections. In addition to helping create detailed maps of brain circuitry, the engineering of these cells has been used to cure blindness in mice, and could point the way to cures for Parkinson’s disease or Alzheimer’s disease. On the horizon: ways of connecting to the brain via prosthetics.

By inserting genes for light-sensitive proteins into brain cells, neurons can be selectively activated or de-activated with fiber-optic implants. Check out Boyden’s demonstration at TED2011 below.

Cellular Mechanisms of Long Term Memory Storage

March 13, 2012 | by

Dr. Menahem Segal, head of the Laboratory of Neuronal Plasticity at the Weizmann Institute of Science in Israel, studies the neuronal basis of long term memory in the brain. Of particular interest are conditions that are associated with deterioration of memory systems, such as those occurring in Alzheimer’s disease patients and mentally retarded children.

Neurons

Study Suggests that Alzheimer’s Disease Spreads Through the Brain

February 13, 2012 | by

Scientists have long debated whether Alzheimer’s disease starts in separate regions of the brain independently and at different times, or if it begins in one region and then spreads. Data from researchers at Columbia University Medical Center supports the latter model, showing that abnormal tau protein — a key feature observed in the brains of patients with Alzheimer’s disease — propagates along anatomically connected networks, between connected and vulnerable neurons. The study was published earlier this month in the online journal PLoS ONE [1].

Neural network in human brainImage credit: Neurons network in human brain via Shutterstock

Another Nail in the Coffin of the MMR-Autism Link

November 21, 2011 | by

While the alleged link between vaccines — particularly the measles, mumps, and rubella (MMR) vaccine — and autism has been thoroughly discredited in more than 20 well-conducted studies of vaccine side effects [1], fears about the side effects of vaccination nevertheless remain a major factor influencing the healthcare decisions some parents make. This has led to an increasing percentage of unvaccinated children in the U.S. in recent years, which in turn has ramifications for public health.

Brain scans

A recent study published in the Journal of the American Medical Association, however, sheds new light on physiological roots — though not causes — of autism [2], and in so doing rules out the potential for any link between vaccination and development of the disease. In the study, researchers examined the size and number of neurons in the prefrontal cortex of young deceased males with autism, and compared the data to that obtained from young deceased non-autistic males.