Study Identifies Likely Mechanism Underlying Resveratrol Activity

February 8, 2012 | by

National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging. Rather, the authors found that resveratrol inhibits certain types of proteins known as phosphodiesterases (PDEs), enzymes that help regulate cell energy.

These findings may help settle the debate regarding resveratrol’s biochemistry and pave the way for resveratrol-based medicines. The chemical has received significant interest from pharmaceutical companies for its potential to combat diabetes, inflammation, and cancer. The study appears in the February 3rd issue of the journal Cell [1].

Resveratrol

Inactivity May Encourage the Body to Create New Fat in Fat Cells

January 4, 2012 | by

It’s obvious that obese people more have fat than non-obese people, but it’s not as clear how it happens. Do obese individuals have more adipocytes (fat cells) than lean people, or do they have the same number of adipocytes, just larger ones? It turns out to be both. But the way that comes to pass is just being worked out by scientists. Engineering Professor Dr. Amit Gefen and his colleagues at Tel Aviv University recently demonstrated in a mouse cell line model that preadipocytes (precursors to fat cells) subjected to prolonged periods of “mechanical stretching loads” — the kind of weight we put on our body tissues when we sit or lie down — differentiate significantly faster, and retain significantly larger fat droplets, than those that are not. The research was published in the American Journal of Physiology — Cell Physiology [1].

Lounging couple

New Strategic Plan for NIH Obesity Research Seeks to Curb Epidemic

April 10, 2011 | by

To combat the obesity epidemic, the National Institutes of Health is encouraging diverse scientific investigations through a new Strategic Plan for NIH Obesity Research.

More than one-third of adults in the United States and nearly 17 percent of the nation’s children are now obese, which increases a person’s chance of developing many health problems, including type 2 diabetes, heart disease, high blood pressure, fatty liver disease, and some cancers. Although American obesity rates leveled off in 2007, in 2008, obesity-related medical costs were an estimated $147 billion. Government, nonprofit and community groups, businesses, health care professionals, schools, families, and individuals are taking action to address this public health problem — and research can provide the foundation for these efforts.

New Strategic NIH Plan to Fight Diabetes

March 31, 2011 | by

A new strategic plan to guide diabetes-related research over the next decade was announced recently by the National Institutes of Health. The plan, developed by a federal work group led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), identifies research opportunities with the greatest potential to benefit the millions of Americans who are living with or at risk for diabetes and its complications.

Abnormal Heart Rate Turbulence May Predict Heart Disease

March 2, 2011 | by

According to a study in the February 15 edition of the Journal of Cardiovascular Electrophysiology, abnormal heart rate turbulence is associated with an increased risk of heart disease death in otherwise older, low-risk individuals [1]. Additional studies need to be done in order to understand whether this potential biomarker will be a clinically valuable tool.

Electrocardiogram