Have you ever heard a person in poor health being told “Well, you’ve got to stay positive, that will help”? This seemingly common idea is currently under significant scientific investigation. Indeed, the debate about the degree to which psychological processes can directly influence physical health has received special attention recently. A special supplement of the Annals of Behavioural Medicine directly addressed this topic in February this year and a recent article in the Lancet explored this issue, cautioning us that the relationship between a positive psychological orientation and cancer survival remains unclear [1].