Personalized Medicine Approach Provides More Benefit for Patients with High Cholesterol than Current Guidelines

February 24, 2010 | by
ResearchBlogging.org

Statins are a class of drugs that lower cholesterol and thereby reduce the risk of heart disease and stroke. They work by preventing the synthesis of low-density lipoprotein (LDL or “bad cholesterol”) in the liver and promoting its clearance from the blood. They are the most effective cholesterol-lowering drugs currently available and are the cornerstone of the National Heart, Lung, and Blood Institute’s National Cholesterol Education Program (NCEP) treatment guidelines.

The NCEP recommends a “treat-to-target” strategy, in which patients are given specific statin doses to achieve a desired level of LDL cholesterol in the blood. In this case, low LDL cholesterol is the “target.” Yet some physicians are questioning whether treating to any target is the best approach to fighting disease. A recent study in the Annals of Internal Medicine suggests that “tailored treatment”, an approach attempts to practice personalized medicine by estimating three factors, is more effective than a treat-to-target strategy [1].

You Can Help Improve the Health of America: Healthy People 2020

December 3, 2009 | by

The U.S. Department of Health and Human Services (HHS) is inviting people to submit comments and suggestions as part of the collaborative process for Healthy People 2020. Healthy People is consortium of diverse, motivated and dedicated agencies and organizations committed to working together to help achieve health goals and objectives for the nation. As a national initiative, Healthy People 2020’s success depends on public input.

Healthy People 2020

Every 10 years, the HHS leverages scientific insights and lessons learned from the past decade, along with knowledge of new and emerging issues, data, trends and innovations to set the nation’s health priorities. In 2007 and 2008, the Healthy People 2020 framework was established, consisting of the vision, mission and overarching goals. In 2009, specific objectives and strategies to achieve them were developed. This month, the HHS is requesting public comments on the draft set of proposed objectives for Healthy People 2020. You are invited to comment on the proposed objectives and topic areas and suggest additional objectives and/or topic areas that you feel are missing.

Health Highlights – September 8th, 2009

September 9, 2009 | by

Health Highlights is a biweekly summary of particularly interesting articles from credible sources of health and medical information that we follow & read. For a complete list of recommeded sources, see our links page.

Health Highlights

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New Genes Associated with Blood Pressure and Hypertension

May 29, 2009 | by

High blood pressure or hypertension affects more than one in three people worldwide and is a major cause of strokes, heart attacks and heart failure [1]. The degree with which blood pressure traits can be inherited suggests a genetic component. However, limited consistent evidence of genes associated with blood pressure have been produced. A new study in the journal Nature Genetics reports for the first time a number of genes showing significant associations with blood pressure and hypertension across the genome [2].

blood-pressure

Although large-scale genome-wide association studies (GWAS) have been used successfully to identify genes associated with common diseases and traits, studies on blood pressure or hypertension have failed to identify loci at a genome-wide significant threshold (p-value < 5 x 10-8). The significance of GWAS data relies on several variables, including the accuracy of phenotypic measures, density of markers and size of the study population. Thus, if blood pressure variation in the general population is due to multiple genetic factors with small effects, a very large sample size is needed to identify them.

Brain Toniq Review: The Science Behind the Think Drink

April 9, 2009 | by

The ability to multitask and mentally juggle multiple demands is essential in today’s fast-paced world. At the same time, we’re bombarded with information that can both distract and overload our focus and attention.

Many of us need a caffeine “boost” in the morning or throughout the day to maintain mental focus. However, drinking too much coffee or tea leaves you feeling like you need to do a couple of laps around the building.

brain-toniq

And although coffee consumption offers a number of potential health benefits, many of us drink more than enough of it on a daily basis. Energy drinks are an alternative option. However, their effects on cognitive performance are principally related to the presence of caffeine [1].

Enter Brain Toniq

Brain Toniq bills itself as the world’s first and only botanical-based, non-caffeinated functional “think drink”, specifically designed to increase mental focus, function and clarity. According to the Brain Toniq website:

Formulated out of plant extracts and natural compounds, the ingredients in Brain Toniq have a long, proven history for their effects on increasing brain power and cognition.

I’d previously heard about Brain Toniq and was intrigued at the idea of an energy drink designed to increase cognitive performance. Additionally, the Brain Toniq website references peer-reviewed research studies that examine many of the ingredients. When I contacted the company, they were kind enough to send me a sample to review.