Building a Brain in a Supercomputer

March 16, 2011 | by

Mental illness, memory, perception: they’re made of neurons and electric signals. Henry Markram claims these mysteries of the mind can be solved — and soon. He is building a detailed, realistic computer model of the human brain and its one hundred trillion — that’s 100,000,000,000,000 — synapses.

Markram is the director of the Blue Brain Project at Ecole polytechnique federale de Lausanne (EPFL), one of two Swiss Federal Institutes of Technology located in Lausanne, Switzerland. Founded in 2005 by the Brain and Mind Institute at the EPFL, Blue Brain is a supercomputing project that to study the brain’s architectural and functional principles, and reverse engineer it in order to understand brain function and dysfunction. Blue Brain can model components of the mammalian brain in precise cellular detail and simulate neuronal activity in 3D. Soon Blue Brain will be able to simulate a whole rat brain in real time.

Growth Factor Enhances Memory, Prevents Forgetting in Rats

January 31, 2011 | by

A naturally occurring growth factor significantly boosted retention and prevented forgetting of a fear memory when injected into rats’ memory circuitry during time-limited windows when memories become fragile and changeable. In a study funded by the National Institutes of Health (NIH), animals treated with insulin-like growth factor (IGF2) excelled at remembering to avoid a location where they had previously experienced a mild shock [1].

Mapping Connections in the Human Brain

July 31, 2008 | by

The first high-resolution structural connection map of the human cerebral cortex was published earlier this month in the journal PLoS Biology. The study reveals regions that are highly connected and central, forming a structural core network [1]. Intriguingly, this core network consists of many areas that are more active when we’re at rest than when we’re engaged in a task that requires concentration.