Supplemental Vitamin E and A, Worth The Risk?

Perhaps among the most confusing of nutrition and wellness decisions that the average consumer must make is whether to take dietary supplements. The available information is deeply contradictory; while some supplements — like folic acid for pregnant women and vitamin D for babies — are considered nearly essential in medical care, research suggests that other supplements may be ineffective or even deleterious to health. A recent research summary published in The Medical Letter On Drugs and Therapeutics may help consumers and practitioners to wade through the conflicting information on supplements, as many supplements have both risks and benefits associated with their use [1].

Vitamins E and A

Oxidative Stress in Children with Celiac Disease

ResearchBlogging.org

Celiac disease is a genetic digestive disorder triggered by consumption of the protein gluten, which is found in bread, pasta, cookies, pizza crust and many other foods containing wheat, barley or rye. Researchers now report that there is a factor independent of diet that contributes to oxidative stress in celiac disease patients; children with celiac disease have higher than normal levels of two oxidative DNA damage biomarkers, regardless of what they eat [1].

Celiac disease is an autoimmune disease in which the consumption of gluten — a protein found in all forms of wheat, including spelt, kamut, semolina and triticale, as well as in barley and rye — induces an inflammatory reaction that destroys the gut. It occurs in almost 1% of the population, although in the United States as many as 97% of cases remain undiagnosed. Most autoimmune diseases are thought to be caused by an interaction between a genetic predisposition and an environmental trigger, but celiac disease is the only one for which the environmental trigger is known: gluten.

Study Showing Antioxidant Vitamins Increase Mortality Flawed

A study published in The Journal of the American Medical Association (JAMA) made headlines recently. The review, “Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis”, assessed the effect of antioxidant supplementation on mortality in randomized primary and secondary prevention trials and concluded that beta carotene, vitamin A and vitamin E supplementation are positively correlated with death and may increase mortality.

Vitamin A

Vitamin A consists of a group of compounds that play an important role in vision, bone growth, reproduction, cell division and cell differentiation [1]. It helps to regulate the immune system and may also help lymphocytes (meaning a type of white blood cell) better fight infection [2].

Vitamins

Vitamins are essential biomolecules that act as both catalysts (meaning a substance that increases or decreases the rate of a chemical reaction) and substrates (meaning a molecule that is acted upon by an enzyme) in chemical reactions and are required in very small amounts for essential metabolic reactions in the body. With the exception of biotin, vitamin D and vitamin K, the body cannot manufacture vitamins — they must be obtained through food or nutritional supplementation. There are 13 known vitamins categorized as either fat-soluble (meaning absorbed through the intestinal tract with the help of lipids) and include vitamin A, vitamin D, vitamin E and vitamin K or water-soluble (meaning dissolves easily in water) and include eight B vitamins and vitamin C. The body stores fat-soluble vitamins for long periods of time while water-soluble vitamins (excluding vitamin B12) remain in the body for a short period of time and must be replenished more frequently.