A study published in The Journal of the American Medical Association (JAMA) made headlines recently. The review, “Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis”, assessed the effect of antioxidant supplementation on mortality in randomized primary and secondary prevention trials and concluded that beta carotene, vitamin A and vitamin E supplementation are positively correlated with death and may increase mortality.
March is National Colorectal Cancer Awareness Month
March 8, 2007 | by
The goal of the annual National Colorectal Cancer Awareness Month is to make people aware of colorectal cancer and to encourage people to learn more about how to reduce their risk of colorectal cancer (CRC) through regular screening and a healthy lifestyle. The results of the National Health Interview Survey (NHIS) administered to 32,374 adults 18 years of age or older in 2000 showed that colorectal cancer screening is underused [1]. Just over 60% of adults had ever had colorectal cancer testing. Only 44% of men and 37% of women greater than 75 years of age were current for testing. Colorectal cancer screening is very important. If colorectal cancer is allowed to metastasize (meaning to spread to other parts of the body), the 5-year survival rate is less than 10%. However, if colorectal cancer is found early, the 5-year survival rate is greater than 90% [2].
Vitamin C
February 25, 2007 | by
Vitamin C is a water-soluble vitamin that is used in many tissues throughout the body. The adrenal gland contains the highest concentration of vitamin C, and the vitamin plays a crucial role in both the adrenal cortex and adrenal medulla [1]. Humans are one of the few species that cannot manufacture the vitamin in the body and must depend on diet or nutritional supplementation as a source of vitamin C. The best sources of vitamin C are fresh fruit (especially in the citrus family, including oranges, lemons, limes and tangerines), strawberries, cantaloupe and currants. Green leafy vegetables, including Brussel sprouts, collard greens, lettuce, cabbage, peas and asparagus, are also good sources.
Dichloroacetate Not Ready for Therapeutic Use
February 11, 2007 | by
Dichloroacetate has been in the headlines recently, reported to be a cheap, effective cancer cure. The article was published in both print and on the website NewScientist.com, and ran with the headline “Cheap, safe drug kills most cancers”, implying incorrectly that it can kill tumor cells in humans.
Researchers at the University of Alberta in Edmonton, Canada, recently reported that they found a cheap and easy drug to produce that is able to cause tumor regression in lung, breast and brain tumor cells grown in culture and lung tumors grown in immunocompromised rats. The drug, Dichloroacetate (DCA), targets mitochondria (meaning an organelle in the cell that produces energy) and induces apoptosis (meaning cell death), decreases proliferation and selectively inhibits cancer cell growth. It did not have any effects on normal, non-cancerous tissue. The findings were published in the January edition of the journal Cancer Cell.
Cancer cells don’t use mitochondria for energy, instead using glycolysis (meaning the initial process of most of carbohydrate metabolism), which is less effective and more wasteful. Researchers have long believed this occurred because mitochondria in cancer cells were damaged. However, this new data suggests that the mitochondria in cancer cells are dormant and DCA reactivates them.
Sinus Congestion
February 9, 2007 | by
The sinuses are hollow spaces located inside the bones in the skull to either side of the nose, behind and in between the eyes, in the forehead and at the back of the nasal cavity. The sinuses are lined with a moist, thin layer of tissue called a mucous membrane, which not only humidifies the air as you breathe it in, but also produces mucus to trap irritants such as dust, pollen and bacteria. The sinuses are lined with microscopic hairs called cilia. The function of cilia is to move mucus to flush the sinuses and nasal passageways of trapped irritants.
Sinus congestion is the blockage of one or more of the nasal passageways as a result of inflammation and swelling of the sinus tissues, secretion of mucus or a deviated septum (meaning obstruction of the nasal passage by the membranous ridge of cartilage in the nose that separates the nasal cavity into the two nostrils). Sinus congestion leads to impaired flow of mucus out of the sinuses. The build up of mucus in the sinuses causes increased pressure. Also, bacteria can become trapped and infect the mucous membrane, a condition termed sinusitis.
